Mechanistic Insights on the Anticancer Effects of Metformin in Primary Breast Cancer Cells

Mechanistic Insights on the Anticancer Effects of Metformin in Primary Breast Cancer Cells

Metabolic disorders, such as obesity, type 2 diabetes (T2D) and metabolic syndrome, have been implicated in breast cancer (BC) progression. In this regard, insulin has been shown to promote mitogenic and metastatic responses in BC through diverse signaling pathways. Moreover, high levels of insulin...

Full description

Bibliographic Details
Main Authors: Francesca Cirillo, Domenica Scordamaglia, Marianna Talia, Maria Francesca Santolla, Lucia Muglia, Azzurra Zicarelli, Salvatore De Rosis, Asia Spinelli, Francesca Giordano, Anna Maria Miglietta, Marcello Maggiolini, Rosamaria Lappano
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Biology and Life Sciences Forum
Subjects:
breast cancer
metformin
insulin/insulin receptor
tumor microenvironment
Online Access:https://www.mdpi.com/2673-9976/21/1/18

Internet

https://www.mdpi.com/2673-9976/21/1/18

Similar Items