The integrin receptor beta7 subunit mediates airway remodeling and hyperresponsiveness in allergen exposed mice
Abstract Background Fibroblast differentiation to a myofibroblast phenotype is a feature of airway remodeling in asthma. Lung fibroblasts express the integrin receptor α4β7 and fibronectin induces myofibroblast differentiation via this receptor. Objectives To investigate the role of the β7 integrin...
| Главные авторы: | , , , |
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| Формат: | Статья |
| Язык: | English |
| Опубликовано: |
BMC
2024-07-01
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| Серии: | Respiratory Research |
| Предметы: | |
| Online-ссылка: | https://doi.org/10.1186/s12931-024-02899-8 |