Establishment and Molecular Characterization of an In Vitro Model for PARPi-Resistant Ovarian Cancer

Establishment and Molecular Characterization of an In Vitro Model for PARPi-Resistant Ovarian Cancer

Overcoming PARPi resistance is a high clinical priority. We established and characterized comparative in vitro models of acquired PARPi resistance, derived from either a <i>BRCA1</i>-proficient or <i>BRCA1</i>-deficient isogenic background by long-term exposure to olaparib. W...

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Bibliographic Details
Main Authors: Daniel Martin Klotz, Franziska Maria Schwarz, Anna Dubrovska, Kati Schuster, Mirko Theis, Alexander Krüger, Oliver Kutz, Theresa Link, Pauline Wimberger, Stephan Drukewitz, Frank Buchholz, Jürgen Thomale, Jan Dominik Kuhlmann
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cancers
Subjects:
ovarian cancer
PARPi resistance
cisplatin
Online Access:https://www.mdpi.com/2072-6694/15/15/3774

Internet

https://www.mdpi.com/2072-6694/15/15/3774

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