Buffy Coat Transcriptomic Analysis Reveals Alterations in Host Cell Protein Synthesis and Cell Cycle in Severe COVID-19 Patients

Buffy Coat Transcriptomic Analysis Reveals Alterations in Host Cell Protein Synthesis and Cell Cycle in Severe COVID-19 Patients

Transcriptome studies have reported the dysregulation of cell cycle-related genes and the global inhibition of host mRNA translation in COVID-19 cases. However, the key genes and cellular mechanisms that are most affected by the severe outcome of this disease remain unclear. For this work, the RNA-s...

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Bibliographic Details
Main Authors: Liliane Tavares de Faria Cavalcante, Guilherme Cordenonsi da Fonseca, Luciane Almeida Amado Leon, Andreza Lemos Salvio, Otávio José Brustolini, Alexandra Lehmkuhl Gerber, Ana Paula de Campos Guimarães, Carla Augusta Barreto Marques, Renan Amphilophio Fernandes, Carlos Henrique Ferreira Ramos Filho, Rafael Lopes Kader, Marisa Pimentel Amaro, João Paulo da Costa Gonçalves, Soniza Vieira Alves-Leon, Ana Tereza Ribeiro Vasconcelos
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
COVID-19
SARS-CoV-2
RNA-seq
lncRNA
biomarkers
buffy coat
Online Access:https://www.mdpi.com/1422-0067/23/21/13588

Internet

https://www.mdpi.com/1422-0067/23/21/13588

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