Design and Synthesis of Benzene Homologues Tethered with 1,2,4-Triazole and 1,3,4-Thiadiazole Motifs Revealing Dual MCF-7/HepG2 Cytotoxic Activity with Prominent Selectivity via Histone Demethylase LSD1 Inhibitory Effect

Design and Synthesis of Benzene Homologues Tethered with 1,2,4-Triazole and 1,3,4-Thiadiazole Motifs Revealing Dual MCF-7/HepG2 Cytotoxic Activity with Prominent Selectivity via Histone Demethylase LSD1 Inhibitory Effect

In this study, an efficient multistep synthesis of novel aromatic tricyclic hybrids incorporating different biological active moieties, such as 1,3,4-thiadiazole and 1,2,4-triazole, was reported. These target scaffolds are characterized by having terminal lipophilic or hydrophilic parts, and their s...

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Bibliographic Details
Main Authors: Mosa Alsehli, Ateyatallah Aljuhani, Saleh K. Ihmaid, Shahenda M. El-Messery, Dina I. A. Othman, Abdel-Aziz A. A. El-Sayed, Hany E. A. Ahmed, Nadjet Rezki, Mohamed R. Aouad
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
1,2,4-triazoles
1,3,4-thiadiazoles
LSD1
melanoma
tris-substituted analogues
anticancer activity
Online Access:https://www.mdpi.com/1422-0067/23/15/8796

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https://www.mdpi.com/1422-0067/23/15/8796

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