Bruton’s Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia

Bruton’s Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia

Bruton’s tyrosine kinase (Btk) is a cytoplasmic kinase expressed in B cells and myeloid cells. It is essential for B cell development and natural antibody-mediated host defense against bacteria in humans and mice, but little is known about the role of Btk in innate host defense in vivo. Previous stu...

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Bibliographic Details
Main Authors: Alexander P. de Porto, Zhe Liu, Regina de Beer, Sandrine Florquin, Joris J. T. H. Roelofs, Onno J. de Boer, Joke M. M. den Haan, Rudi W. Hendriks, Cornelis van ‘t Veer, Tom van der Poll, Alex F. de Vos
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
BTK - Bruton’s tyrosine kinase
X-linked immunodeficiency
natural antibodies
Streptococcus pneumoniae
pneumonia
sepsis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.723967/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.723967/full

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