Site-selective oral delivery of therapeutic antibodies to the inflamed colon via a folic acid-grafted organic/inorganic hybrid nanocomposite system

Site-selective oral delivery of therapeutic antibodies to the inflamed colon via a folic acid-grafted organic/inorganic hybrid nanocomposite system

This study aimed to develop a pH-responsive folic acid-grafted organic/inorganic hybrid nanocomposite system for site-selective oral delivery of therapeutic antibodies. A folic acid-grafted aminoclay (FA-AC) was prepared via an in situ sol‒gel method. Then, a drug-loaded nanocomplex was prepared via...

Full description

Bibliographic Details
Main Authors: Sang Hoon Lee, Jae Geun Song, Hyo-Kyung Han
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Infliximab
Aminoclay
Colonic delivery
TNF-α
Inflammation
Folate receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352200274X

Internet

http://www.sciencedirect.com/science/article/pii/S221138352200274X

Similar Items