X-ray Crystallographic Structure of α-Helical Peptide Stabilized by Hydrocarbon Stapling at <i>i</i>,<i>i</i> + 1 Positions

X-ray Crystallographic Structure of α-Helical Peptide Stabilized by Hydrocarbon Stapling at <i>i</i>,<i>i</i> + 1 Positions

Hydrocarbon stapling is a useful tool for stabilizing the secondary structure of peptides. Among several methods, hydrocarbon stapling at <i>i</i>,<i>i</i> + 1 positions was not extensively studied, and their secondary structures are not clarified. In this study, we investiga...

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Bibliographic Details
Main Authors: Yui Makura, Atsushi Ueda, Takuma Kato, Akihiro Iyoshi, Mei Higuchi, Mitsunobu Doi, Masakazu Tanaka
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
peptide
α-helix
hydrocarbon stapling
ring-closing metathesis
<i>i</i>,<i>i</i> + 1 staple
X-ray structure
Online Access:https://www.mdpi.com/1422-0067/22/10/5364

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https://www.mdpi.com/1422-0067/22/10/5364

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