Oxyimperatorin attenuates LPS-induced microglial activation in vitro and in vivo via suppressing NF-κB p65 signaling

Oxyimperatorin attenuates LPS-induced microglial activation in vitro and in vivo via suppressing NF-κB p65 signaling

Background: Microglia-mediated neuroinflammation is an important pathological feature in many neurological diseases; thus, suppressing microglial activation is considered a possible therapeutic strategy for reducing neuronal damage. Oxyimperatorin (OIMP) is a member of furanocoumarin, isolated from...

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Bibliographic Details
Main Authors: Changcheng Lu, Chen Huang, Shuhui Qu, Huiyuan Lin, Hai-Jing Zhong, Cheong-Meng Chong
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Microglia
Neuroinflammation
Oxyimperatorin
Pro-inflammatory cytokines
NF-κB p65
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224002634

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http://www.sciencedirect.com/science/article/pii/S0753332224002634

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