Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity

Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity

Formaldehyde (FA) is known to exert cytotoxicity through DNA damage. Here, the authors show that FA also triggers cellular redox imbalance by reacting with glutathione (GSH), and that FA cytotoxicity is prevented by GSH synthesis and by ADH5, an enzyme that metabolizes FA-GSH products.

Bibliographic Details
Main Authors: Carla Umansky, Agustín E. Morellato, Matthias Rieckher, Marco A. Scheidegger, Manuela R. Martinefski, Gabriela A. Fernández, Oleg Pak, Ksenia Kolesnikova, Hernán Reingruber, Mariela Bollini, Gerry P. Crossan, Natascha Sommer, María Eugenia Monge, Björn Schumacher, Lucas B. Pontel
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-28242-7

Internet

https://doi.org/10.1038/s41467-022-28242-7

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