Aldosterone-Induced Sarco/Endoplasmic Reticulum Ca2+ Pump Upregulation Counterbalances Cav1.2-Mediated Ca2+ Influx in Mesenteric Arteries

Aldosterone-Induced Sarco/Endoplasmic Reticulum Ca2+ Pump Upregulation Counterbalances Cav1.2-Mediated Ca2+ Influx in Mesenteric Arteries

In mesenteric arteries (MAs), aldosterone (ALDO) binds to the endogenous mineralocorticoid receptor (MR) and increases the expression of the voltage-gated L-type Cav1.2 channel, an essential ion channel for vascular contraction, sarcoplasmic reticulum (SR) Ca2+ store refilling, and Ca2+ spark genera...

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Bibliographic Details
Main Authors: Rogelio Salazar-Enciso, Agustín Guerrero-Hernández, Ana M. Gómez, Jean-Pierre Benitah, Angélica Rueda
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Physiology
Subjects:
calcium sparks
aldosterone (ALDO)
ryanodine receptor
STOCs
Cav1.2 Ca2+ channel
SERCA pump
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.834220/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.834220/full

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