Comparative analysis of adeno-associated virus serotypes for gene transfer in organotypic heart slices

Comparative analysis of adeno-associated virus serotypes for gene transfer in organotypic heart slices

Abstract Background Vectors derived from adeno-associated viruses (AAVs) are widely used for gene transfer both in vitro and in vivo and have gained increasing interest as shuttle systems to deliver therapeutic genes to the heart. However, there is little information on their tissue penetration and...

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Bibliographic Details
Main Authors: Zihou Liu, Kristin Klose, Sebastian Neuber, Meng Jiang, Manfred Gossen, Christof Stamm
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Journal of Translational Medicine
Subjects:
Myocardial slice
Organotypic heart slice culture
Adeno-associated virus
Gene transfer
Gene therapy
Online Access:http://link.springer.com/article/10.1186/s12967-020-02605-4

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http://link.springer.com/article/10.1186/s12967-020-02605-4

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