Innate immune activation by checkpoint inhibition in human patient-derived lung cancer tissues

Innate immune activation by checkpoint inhibition in human patient-derived lung cancer tissues

Although Pembrolizumab-based immunotherapy has significantly improved lung cancer patient survival, many patients show variable efficacy and resistance development. A better understanding of the drug’s action is needed to improve patient outcomes. Functional heterogeneity of the tumor microenvironme...

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Bibliographic Details
Main Authors: Teresa WM Fan, Richard M Higashi, Huan Song, Saeed Daneshmandi, Angela L Mahan, Matthew S Purdom, Therese J Bocklage, Thomas A Pittman, Daheng He, Chi Wang, Andrew N Lane
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
non small cell lung cancer
tumor microenvironment
human macrophage metabolism
stable isotope resolved metabolomics
pembrolizumab
Online Access:https://elifesciences.org/articles/69578

Internet

https://elifesciences.org/articles/69578

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