Rare predicted loss of function alleles in Bassoon (BSN) are associated with obesity

Rare predicted loss of function alleles in Bassoon (BSN) are associated with obesity

Abstract Bassoon (BSN) is a component of a hetero-dimeric presynaptic cytomatrix protein that orchestrates neurotransmitter release with Piccolo (PCLO) from glutamatergic neurons throughout the brain. Heterozygous missense variants in BSN have previously been associated with neurodegenerative disord...

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Bibliographic Details
Main Authors: Na Zhu, Charles A. LeDuc, Ilene Fennoy, Blandine Laferrère, Claudia A. Doege, Yufeng Shen, Wendy K. Chung, Rudolph L. Leibel
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:npj Genomic Medicine
Online Access:https://doi.org/10.1038/s41525-023-00376-7

Internet

https://doi.org/10.1038/s41525-023-00376-7

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