Computer-Aided Discovery of Small Molecule Inhibitors of Transcriptional Activity of TLX (NR2E1) Nuclear Receptor

Computer-Aided Discovery of Small Molecule Inhibitors of Transcriptional Activity of TLX (NR2E1) Nuclear Receptor

Orphan nuclear receptor TLX (NR2E1) plays a critical role in the regulation of neural stem cells (NSC) as well as in the development of NSC-derived brain tumors. In the last years, new data have emerged implicating TLX in prostate and breast cancer. Therefore, inhibitors of TLX transcriptional activ...

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Bibliographic Details
Main Authors: Evgenia Dueva, Kriti Singh, Anastasia Kalyta, Eric LeBlanc, Paul S. Rennie, Artem Cherkasov
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
TLX
NR2E1
transcriptional factor
nuclear receptor
structure-based drug design
prostate cancer
Online Access:https://www.mdpi.com/1420-3049/23/11/2967

Internet

https://www.mdpi.com/1420-3049/23/11/2967

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