Computer-Aided Discovery of Small Molecule Inhibitors of Transcriptional Activity of TLX (NR2E1) Nuclear Receptor
Orphan nuclear receptor TLX (NR2E1) plays a critical role in the regulation of neural stem cells (NSC) as well as in the development of NSC-derived brain tumors. In the last years, new data have emerged implicating TLX in prostate and breast cancer. Therefore, inhibitors of TLX transcriptional activ...
Main Authors: | Evgenia Dueva, Kriti Singh, Anastasia Kalyta, Eric LeBlanc, Paul S. Rennie, Artem Cherkasov |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-11-01
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Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/23/11/2967 |
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