Novel Selective and Low-Toxic Inhibitor of <i>Lm</i>CPB2.8ΔCTE (CPB) One Important Cysteine Protease for <i>Leishmania</i> Virulence

Novel Selective and Low-Toxic Inhibitor of <i>Lm</i>CPB2.8ΔCTE (CPB) One Important Cysteine Protease for <i>Leishmania</i> Virulence

Leishmaniasis is a highly prevalent, yet neglected disease caused by protozoan parasites of the genus <i>Leishmania</i>. In the search for newer, safer, and more effective antileishmanial compounds, we herein present a study of the mode of action in addition to a detailed structural and...

Full description

Bibliographic Details
Main Authors: Vitor Partite Moreira, Michele Ferreira da Silva Mela, Luana Ribeiro dos Anjos, Leonardo Figueiredo Saraiva, Angela M. Arenas Velásquez, Predrag Kalaba, Anna Fabisiková, Leandro da Costa Clementino, Mohammed Aufy, Christian Studenik, Natalie Gajic, Alexander Prado-Roller, Alvicler Magalhães, Martin Zehl, Ingrid Delbone Figueiredo, Amanda Martins Baviera, Eduardo Maffud Cilli, Marcia A. S. Graminha, Gert Lubec, Eduardo R. Perez Gonzalez
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Biomolecules
Subjects:
<i>Leishmania</i> cysteine protease inhibition
guanidines
X-ray and NMR conformational study
molecular docking
leishmanicidal activity
Online Access:https://www.mdpi.com/2218-273X/12/12/1903

Internet

https://www.mdpi.com/2218-273X/12/12/1903

Similar Items