Inhibition of SARS-CoV-2 infection in human iPSC-derived cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoarchitecture and beating

Inhibition of SARS-CoV-2 infection in human iPSC-derived cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoarchitecture and beating

SARS-CoV-2 infects cardiac cells and causes heart dysfunction. Conditions such as myocarditis and arrhythmia have been reported in COVID-19 patients. The Sigma-1 receptor (S1R) is a ubiquitously expressed chaperone that plays a central role in cardiomyocyte function. S1R has been proposed as a thera...

Full description

Bibliographic Details
Main Authors: José Alexandre Salerno, Thayana Torquato, Jairo R. Temerozo, Livia Goto-Silva, Karina Karmirian, Mayara A. Mendes, Carolina Q. Sacramento, Natalia Fintelman-Rodrigues, Letícia R Q. Souza, Isis M. Ornelas, Carla P. Veríssimo, Luiz Guilherme H S. Aragão, Gabriela Vitória, Carolina S G. Pedrosa, Suelen da Silva Gomes Dias, Vinicius Cardoso Soares, Teresa Puig-Pijuan, Vinícius Salazar, Rafael Dariolli, Diogo Biagi, Daniel R. Furtado, Luciana Barreto Chiarini, Helena L. Borges, Patrícia T. Bozza, Marilia Zaluar P. Guimarães, Thiago M.L. Souza, Stevens K. Rehen
Format: Article
Language:English
Published: PeerJ Inc. 2021-12-01
Series:PeerJ
Subjects:
Sigma-1 Receptor
IPSC
Cardiomyocyte
SARS-CoV-2
Online Access:https://peerj.com/articles/12595.pdf

Internet

https://peerj.com/articles/12595.pdf

Similar Items