FMR1 expression in human granulosa cells increases with exon 1 CGG repeat length depending on ovarian reserve

FMR1 expression in human granulosa cells increases with exon 1 CGG repeat length depending on ovarian reserve

Abstract Background Fragile-X-Mental-Retardation-1- (FMR1)-gene is supposed to be a key gene for ovarian reserve and folliculogenesis. It contains in its 5’-UTR a triplet-base-repeat (CGG), that varies between 26 and 34 in general population. CGG-repeat-lengths with 55–200 repeats (pre-mutation = PM...

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Bibliographic Details
Main Authors: Julia Rehnitz, Diego D. Alcoba, Ilma S. Brum, Jens E. Dietrich, Berthe Youness, Katrin Hinderhofer, Birgitta Messmer, Alexander Freis, Thomas Strowitzki, Ariane Germeyer
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Reproductive Biology and Endocrinology
Subjects:
FMR1 expression
Granulosa cells
FMR1 CGG repeat length
FMR1 genotype
Online Access:http://link.springer.com/article/10.1186/s12958-018-0383-5

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