Functional Analysis of IRF1 Reveals its Role in the Activation of the Type I IFN Pathway in Golden Pompano, <i>Trachinotus ovatus</i> (Linnaeus 1758)

Functional Analysis of IRF1 Reveals its Role in the Activation of the Type I IFN Pathway in Golden Pompano, <i>Trachinotus ovatus</i> (Linnaeus 1758)

Interferon (IFN) regulatory factor 1 (IRF1), a transcription factor with a novel helix–turn–helix DNA-binding domain, plays a crucial role in innate immunity by regulating the type I IFN signaling pathway. However, the regulatory mechanism through which IRF1 regulates type I IFN in fish is not yet e...

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Bibliographic Details
Main Authors: Ke-Cheng Zhu, Nan Zhang, Bao-Suo Liu, Liang Guo, Hua-Yang Guo, Shi-Gui Jiang, Dian-Chang Zhang
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Trachinotus ovatus</i>
IRF1
type I IFN
mutation analyses
EMSA
Online Access:https://www.mdpi.com/1422-0067/21/7/2652

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https://www.mdpi.com/1422-0067/21/7/2652

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