The novel KV7 channel activator URO-K10 exerts enhanced pulmonary vascular effects independent of the KCNE4 regulatory subunit

The novel KV7 channel activator URO-K10 exerts enhanced pulmonary vascular effects independent of the KCNE4 regulatory subunit

KV7 channels exert a pivotal role regulating vascular tone in several vascular beds. In this context, KV7 channel agonists represent an attractive strategy for the treatment of pulmonary arterial hypertension (PAH). Therefore, in this study, we have explored the pulmonary vascular effects of the nov...

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Bibliographic Details
Main Authors: Marta Villegas-Esguevillas, Suhan Cho, Alba Vera-Zambrano, Jae Won Kwon, Bianca Barreira, Göcken Telli, Jorge Navarro-Dorado, Daniel Morales-Cano, Beatriz de Olaiz, Laura Moreno, Iain Greenwood, Francisco Pérez-Vizcaíno, Sung Joon Kim, Belén Climent, Angel Cogolludo
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
KV7 channel activator
Pulmonary hypertension
Vasodilation
KCNQ
Potassium channels
KCNE4 regulatory subunit
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223007424

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http://www.sciencedirect.com/science/article/pii/S0753332223007424

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