Impaired beta-adrenergic response and decreased L-type calcium current of hypertrophied left ventricular myocytes in postinfarction heart failure

Impaired beta-adrenergic response and decreased L-type calcium current of hypertrophied left ventricular myocytes in postinfarction heart failure

Infarct-induced heart failure is usually associated with cardiac hypertrophy and decreased ß-adrenergic responsiveness. However, conflicting results have been reported concerning the density of L-type calcium current (I Ca(L)), and the mechanisms underlying the decreased ß-adrenergic inotropic respo...

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Bibliographic Details
Main Authors: R.M. Saraiva, N.G.B. Chedid, C.C. Quintero H., L.E. Díaz G., M.O. Masuda
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2003-05-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Ca2+ channel
Heart failure
Hypertrophy
Infarction
Adrenergic receptor
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000500012

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000500012

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