Cisplatin induces mitochondrial deficits in Drosophila larval segmental nerve

Cisplatin induces mitochondrial deficits in Drosophila larval segmental nerve

Cisplatin is an effective chemotherapy drug that induces peripheral neuropathy in cancer patients. In rodent dorsal root ganglion neurons, cisplatin binds nuclear and mitochondrial DNA (mtDNA) inducing DNA damage and apoptosis. Platinum-mtDNA adducts inhibit mtDNA replication and transcription leadi...

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Bibliographic Details
Main Authors: Jewel L. Podratz, Han Lee, Patrizia Knorr, Stephanie Koehler, Steven Forsythe, Kelsey Lambrecht, Suzette Arias, Kiley Schmidt, Gabrielle Steinhoff, Georgiy Yudintsev, Amy Yang, Eugenia Trushina, Anthony Windebank
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Neurobiology of Disease
Subjects:
Mitochondria
Cisplatin
Motor neuron
Drosophila
Axonal trafficking
Membrane potential
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116302364

Internet

http://www.sciencedirect.com/science/article/pii/S0969996116302364

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