Anti-Staphylococcal Activity of the Auranofin Analogue Bearing Acetylcysteine in Place of the Thiosugar: An Experimental and Theoretical Investigation

Anti-Staphylococcal Activity of the Auranofin Analogue Bearing Acetylcysteine in Place of the Thiosugar: An Experimental and Theoretical Investigation

Auranofin (AF, hereafter) is an orally administered chrysotherapeutic agent approved for the treatment of rheumatoid arthritis that is being repurposed for various indications including bacterial infections. Its likely mode of action involves the impairment of the TrxR system through the binding of...

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Bibliographic Details
Main Authors: Lorenzo Chiaverini, Alessandro Pratesi, Damiano Cirri, Arianna Nardinocchi, Iogann Tolbatov, Alessandro Marrone, Mariagrazia Di Luca, Tiziano Marzo, Diego La Mendola
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Molecules
Subjects:
auranofin
gold
antibacterial agents
<i>S. aureus</i>
<i>S. epidermidis</i>
antibiotic resistance
Online Access:https://www.mdpi.com/1420-3049/27/8/2578

Internet

https://www.mdpi.com/1420-3049/27/8/2578

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