Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner

Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner

Prolyl oligopeptidase (PREP) is a serine protease that binds to alpha-synuclein (aSyn) and induces its aggregation. PREP inhibitors have been shown to have beneficial effects in Parkinson’s disease models by enhancing the clearance of aSyn aggregates and modulating striatal dopamine. Additionally, w...

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Bibliographic Details
Main Authors: Ulrika H. Julku, Maria Jäntti, Reinis Svarcbahs, Timo T. Myöhänen
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
dopamine
serine protease
alpha-synuclein
extracellular signal-regulated kinase
protein kinase C
Online Access:https://www.mdpi.com/1422-0067/22/4/1777

Internet

https://www.mdpi.com/1422-0067/22/4/1777

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