Structures, substrates, and regulators of mammalian Sirtuins – opportunities and challenges for drug development

Structures, substrates, and regulators of mammalian Sirtuins – opportunities and challenges for drug development

Sirtuins are NAD+-dependent protein deacetylases regulating metabolism, stress responses, and aging processes. Mammalia have seven Sirtuin isoforms, Sirt1-7, which differ in their substrate specificities and subcellular localizations. The physiological functions of Sirtuins make them interesting the...

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Bibliographic Details
Main Authors: Sebastien eMoniot, Michael eWeyand, Clemens eSteegborn
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-02-01
Series:Frontiers in Pharmacology
Subjects:
Mechanism
Structure
SIRTUIN
Drug Development
activator
inhibitor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00016/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00016/full

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