Post-translational modifications on the retinoblastoma protein

Abstract The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S phase transition and plays critical roles in tumour suppression. It is frequently inactivated in various tumours. The functions of pRb are tightly regulated, where post-translational modifications (PTMs...

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Main Authors: Linbin Zhou, Danny Siu-Chun Ng, Jason C. Yam, Li Jia Chen, Clement C. Tham, Chi Pui Pang, Wai Kit Chu
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Biomedical Science
Subjects:
Online Access:https://doi.org/10.1186/s12929-022-00818-x
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author Linbin Zhou
Danny Siu-Chun Ng
Jason C. Yam
Li Jia Chen
Clement C. Tham
Chi Pui Pang
Wai Kit Chu
author_facet Linbin Zhou
Danny Siu-Chun Ng
Jason C. Yam
Li Jia Chen
Clement C. Tham
Chi Pui Pang
Wai Kit Chu
author_sort Linbin Zhou
collection DOAJ
description Abstract The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S phase transition and plays critical roles in tumour suppression. It is frequently inactivated in various tumours. The functions of pRb are tightly regulated, where post-translational modifications (PTMs) play crucial roles, including phosphorylation, ubiquitination, SUMOylation, acetylation and methylation. Most PTMs on pRb are reversible and can be detected in non-cancerous cells, playing an important role in cell cycle regulation, cell survival and differentiation. Conversely, altered PTMs on pRb can give rise to anomalies in cell proliferation and tumourigenesis. In this review, we first summarize recent findings pertinent to how individual PTMs impinge on pRb functions. As many of these PTMs on pRb were published as individual articles, we also provide insights on the coordination, either collaborations and/or competitions, of the same or different types of PTMs on pRb. Having a better understanding of how pRb is post-translationally modulated should pave the way for developing novel and specific therapeutic strategies to treat various human diseases.
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spelling doaj.art-65563937304245b09d21717b99aafc592022-12-22T03:31:02ZengBMCJournal of Biomedical Science1423-01272022-06-0129111610.1186/s12929-022-00818-xPost-translational modifications on the retinoblastoma proteinLinbin Zhou0Danny Siu-Chun Ng1Jason C. Yam2Li Jia Chen3Clement C. Tham4Chi Pui Pang5Wai Kit Chu6Department of Ophthalmology & Visual Sciences, The Chinese University of Hong KongDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong KongDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong KongDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong KongDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong KongDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong KongDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong KongAbstract The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S phase transition and plays critical roles in tumour suppression. It is frequently inactivated in various tumours. The functions of pRb are tightly regulated, where post-translational modifications (PTMs) play crucial roles, including phosphorylation, ubiquitination, SUMOylation, acetylation and methylation. Most PTMs on pRb are reversible and can be detected in non-cancerous cells, playing an important role in cell cycle regulation, cell survival and differentiation. Conversely, altered PTMs on pRb can give rise to anomalies in cell proliferation and tumourigenesis. In this review, we first summarize recent findings pertinent to how individual PTMs impinge on pRb functions. As many of these PTMs on pRb were published as individual articles, we also provide insights on the coordination, either collaborations and/or competitions, of the same or different types of PTMs on pRb. Having a better understanding of how pRb is post-translationally modulated should pave the way for developing novel and specific therapeutic strategies to treat various human diseases.https://doi.org/10.1186/s12929-022-00818-xRetinoblastomaPhosphorylationUbiquitinationSUMOylationAcetylationMethylation
spellingShingle Linbin Zhou
Danny Siu-Chun Ng
Jason C. Yam
Li Jia Chen
Clement C. Tham
Chi Pui Pang
Wai Kit Chu
Post-translational modifications on the retinoblastoma protein
Journal of Biomedical Science
Retinoblastoma
Phosphorylation
Ubiquitination
SUMOylation
Acetylation
Methylation
title Post-translational modifications on the retinoblastoma protein
title_full Post-translational modifications on the retinoblastoma protein
title_fullStr Post-translational modifications on the retinoblastoma protein
title_full_unstemmed Post-translational modifications on the retinoblastoma protein
title_short Post-translational modifications on the retinoblastoma protein
title_sort post translational modifications on the retinoblastoma protein
topic Retinoblastoma
Phosphorylation
Ubiquitination
SUMOylation
Acetylation
Methylation
url https://doi.org/10.1186/s12929-022-00818-x
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