GOLM1 exacerbates CD8+ T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophages

GOLM1 exacerbates CD8+ T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophages

Abstract The immunosuppressive microenvironment plays an important role in tumor progression and immunotherapy responses. Golgi membrane protein 1 (GOLM1) is correlated to hepatocellular carcinoma (HCC) progression and metastasis. However, little is known about the role of GOLM1 in regulating the im...

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Bibliographic Details
Main Authors: Jinhong Chen, Zhifei Lin, Lu Liu, Rui Zhang, Yan Geng, Minghao Fan, Wenwei Zhu, Ming Lu, Lu Lu, Huliang Jia, Jubo Zhang, Lun-Xiu Qin
Format: Article
Language:English
Published: Nature Publishing Group 2021-11-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00784-0

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https://doi.org/10.1038/s41392-021-00784-0

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