Zika virus impacts extracellular vesicle composition and cellular gene expression in macaque early gestation trophoblasts

Abstract Zika virus (ZIKV) infection at the maternal–placental interface is associated with adverse pregnancy outcomes including fetal demise and pregnancy loss. To determine how infection impacts placental trophoblasts, we utilized rhesus macaque trophoblast stem cells (TSC) that can be differentia...

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Bibliographic Details
Main Authors: Lindsey N. Block, Jenna Kropp Schmidt, Nicholas S. Keuler, Megan C. McKeon, Brittany D. Bowman, Gregory J. Wiepz, Thaddeus G. Golos
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-11275-9