Mutation of <i>PTPN11</i> (Encoding SHP-2) Promotes MEK Activation and Malignant Progression in Neurofibromin-Deficient Cells in a Manner Sensitive to <i>BRAP</i> Mutation

Mutation of <i>PTPN11</i> (Encoding SHP-2) Promotes MEK Activation and Malignant Progression in Neurofibromin-Deficient Cells in a Manner Sensitive to <i>BRAP</i> Mutation

Germline mutations of <i>NF1</i> cause neurofibromatosis type 1 (<i>NF1</i>) through the activation of the <i>RAS</i> signaling pathway, and some <i>NF1</i> patients develop malignant peripheral nerve sheath tumors (MPNSTs). Here, we established subclo...

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Bibliographic Details
Main Authors: Ritsuko Harigai, Ryo Sato, Chikako Hirose, Toshiki Takenouchi, Kenjiro Kosaki, Takanori Hirose, Hideyuki Saya, Yoshimi Arima
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cancers
Subjects:
neurofibromatosis type 1 (<i>NF1</i>)
<i>PTPN11</i>
SHP-2
<i>BRAP</i>
MEK
Online Access:https://www.mdpi.com/2072-6694/14/10/2377

Internet

https://www.mdpi.com/2072-6694/14/10/2377

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