Inflammatory macrophages reprogram to immunosuppression by reducing mitochondrial translation

Inflammatory macrophages reprogram to immunosuppression by reducing mitochondrial translation

Abstract Acute inflammation can either resolve through immunosuppression or persist, leading to chronic inflammation. These transitions are driven by distinct molecular and metabolic reprogramming of immune cells. The anti-diabetic drug Metformin inhibits acute and chronic inflammation through mecha...

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Bibliographic Details
Main Authors: Marlies Cortés, Agnese Brischetto, M. C. Martinez-Campanario, Chiara Ninfali, Verónica Domínguez, Sara Fernández, Raquel Celis, Anna Esteve-Codina, Juan J. Lozano, Julia Sidorova, Gloria Garrabou, Anna-Maria Siegert, Carlos Enrich, Belén Pintado, Manuel Morales-Ruiz, Pedro Castro, Juan D. Cañete, Antonio Postigo
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42277-4

Internet

https://doi.org/10.1038/s41467-023-42277-4

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