Integrating protein copy numbers with interaction networks to quantify stoichiometry in clathrin-mediated endocytosis

Abstract Proteins that drive processes like clathrin-mediated endocytosis (CME) are expressed at copy numbers within a cell and across cell types varying from hundreds (e.g. auxilin) to millions (e.g. clathrin). These variations contain important information about function, but without integration w...

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Bibliographic Details
Main Authors: Daisy Duan, Meretta Hanson, David O. Holland, Margaret E. Johnson
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-09259-w