Overexpression CPT1A reduces lipid accumulation via PPARα/CD36 axis to suppress the cell proliferation in ccRCC

Overexpression CPT1A reduces lipid accumulation via PPARα/CD36 axis to suppress the cell proliferation in ccRCC

Clear cell renal carcinoma (ccRCC) is histologically defined by its cytoplasmic lipid deposits. Lipid metabolism disorder largely increases the risk of ccRCC. In this study, we aimed to investigate the biological functions and molecular mechanisms of carnitine palmitoyl transferase 1A (CPT1A) in ccR...

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Bibliographic Details
Main Authors: Yang Hui, Zhao Hongbo, Ren Zhongkun, Yi Xiaojia, Zhang Qiao, Yang Zhe, Kuang Yingmin, Zhu Yuechun
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2021-12-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
CD36
cholesterol
CPT1A
growth
PPARα
renal cancer
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2021023

Internet

https://www.sciengine.com/doi/10.3724/abbs.2021023

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