DNA topoisomerase 1 represses HIV-1 promoter activity through its interaction with a guanine quadruplex present in the LTR sequence

DNA topoisomerase 1 represses HIV-1 promoter activity through its interaction with a guanine quadruplex present in the LTR sequence

Abstract Background Once integrated in the genome of infected cells, HIV-1 provirus is transcribed by the cellular transcription machinery. This process is regulated by both viral and cellular factors, which are necessary for an efficient viral replication as well as for the setting up of viral late...

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Bibliographic Details
Main Authors: María José Lista, Anne-Caroline Jousset, Mingpan Cheng, Violaine Saint-André, Elouan Perrot, Melissa Rodrigues, Carmelo Di Primo, Danielle Gadelle, Elenia Toccafondi, Emmanuel Segeral, Clarisse Berlioz-Torrent, Stéphane Emiliani, Jean-Louis Mergny, Marc Lavigne
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Retrovirology
Subjects:
Guanine quadruplex
HIV-1 LTR promoter
HIV-1 transcription
HIV-1 latency
DNA topoisomerases
Transcriptional regulation
Online Access:https://doi.org/10.1186/s12977-023-00625-8

Internet

https://doi.org/10.1186/s12977-023-00625-8

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