A transcomplementing gene drive provides a flexible platform for laboratory investigation and potential field deployment

Gene drives raise safety concerns around unintended propagation. Here the authors present a trans-complementing split-gene drive that requires inheritance of separate transgenes to assemble a fully functional drive.

Bibliographic Details
Main Authors: Víctor López Del Amo, Alena L. Bishop, Héctor M. Sánchez C., Jared B. Bennett, Xuechun Feng, John M. Marshall, Ethan Bier, Valentino M. Gantz
Format: Article
Language:English
Published: Nature Portfolio 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13977-7