scGWAS: landscape of trait-cell type associations by integrating single-cell transcriptomics-wide and genome-wide association studies

scGWAS: landscape of trait-cell type associations by integrating single-cell transcriptomics-wide and genome-wide association studies

Abstract Background The rapid accumulation of single-cell RNA sequencing (scRNA-seq) data presents unique opportunities to decode the genetically mediated cell-type specificity in complex diseases. Here, we develop a new method, scGWAS, which effectively leverages scRNA-seq data to achieve two goals...

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Bibliographic Details
Main Authors: Peilin Jia, Ruifeng Hu, Fangfang Yan, Yulin Dai, Zhongming Zhao
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Genome Biology
Subjects:
scGWAS
GWAS
Single-cell RNA sequencing
scRNA-seq
Complex diseases
Cell-type specificity
Online Access:https://doi.org/10.1186/s13059-022-02785-w

Internet

https://doi.org/10.1186/s13059-022-02785-w

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