(−)-Epicatechin and the colonic metabolite 3,4-dihydroxyphenylacetic acid protect renal proximal tubular cell against high glucose-induced oxidative stress by modulating NOX-4/SIRT-1 signalling

(−)-Epicatechin and the colonic metabolite 3,4-dihydroxyphenylacetic acid protect renal proximal tubular cell against high glucose-induced oxidative stress by modulating NOX-4/SIRT-1 signalling

Oxidative stress plays a main role in the pathogenesis of the diabetic nephropathy. The present study investigated the effect of (−)-epicatechin (EC) and the colonic-derived flavonoid metabolites 2,3-dihydroxybenzoic acid, 3,4-dihydroxyphenylacetic acid (DHPAA), and 3-hydroxyphenylpropionic acid on...

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Bibliographic Details
Main Authors: David Álvarez-Cilleros, María Ángeles Martín, Luis Goya, Sonia Ramos
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Journal of Functional Foods
Subjects:
Antioxidant defences
Colonic-derived flavonoid metabolites
Epicatechin
NRK-52E cells
Oxidative injury
Signalling pathways
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464618301907

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http://www.sciencedirect.com/science/article/pii/S1756464618301907

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