Pyruvate Kinase M2 Promotes the Activation of Dendritic Cells by Enhancing IL-12p35 Expression

Pyruvate Kinase M2 Promotes the Activation of Dendritic Cells by Enhancing IL-12p35 Expression

Summary: Dendritic cells (DCs) play a central role in both innate and adaptive immunity. Emerging evidence has demonstrated metabolic reprogramming during DC activation. However, how DC activation is linked with metabolic reprogramming remains unclear. Here we show that pyruvate kinase M2 (PKM2), th...

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Bibliographic Details
Main Authors: Xin Jin, Wenxia Zhang, Yang Wang, Jia Liu, Fengqi Hao, Yunlong Li, Miaomiao Tian, Hengyao Shu, Jiaxin Dong, Yunpeng Feng, Min Wei
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
PKM2
dendritic cell
IL-12
JNK
K433 acetylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306434

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http://www.sciencedirect.com/science/article/pii/S2211124720306434

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