Fenofibrate attenuates doxorubicin-induced cardiac dysfunction in mice via activating the eNOS/EPC pathway

Abstract Endothelial progenitor cells (EPCs) improve endothelial impairment, which in turn restores endothelial function in patients with heart failure (HF). In the present study, we tested whether fenofibrate, with its anti-inflammatory and vasoprotective effects, could improve myocardial function...

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Bibliographic Details
Main Authors: Wen-Pin Huang, Wei-Hsian Yin, Jia-Shiong Chen, Po-Hsun Huang, Jaw-Wen Chen, Shing-Jong Lin
Format: Article
Language:English
Published: Nature Portfolio 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-80984-4