Complement Components C3 and C4 Indicate Vasculitis Manifestations to Distinct Renal Compartments in ANCA-Associated Glomerulonephritis

Complement Components C3 and C4 Indicate Vasculitis Manifestations to Distinct Renal Compartments in ANCA-Associated Glomerulonephritis

Acute kidney injury (AKI) is a common and severe complication of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) causing progressive chronic kidney disease (CKD), end-stage renal disease (ESRD) or death. Pathogenic ANCAs, in particular proteinase 3 (PR3) and myeloperoxidase...

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Bibliographic Details
Main Authors: Samy Hakroush, Désirée Tampe, Peter Korsten, Philipp Ströbel, Björn Tampe
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
acute kidney injury
innate immunity
complement system activation
autoimmune diseases
systemic vasculitis
ANCA-associated glomerulonephritis
Online Access:https://www.mdpi.com/1422-0067/22/12/6588

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https://www.mdpi.com/1422-0067/22/12/6588

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