Targeted therapy of advanced parathyroid carcinoma guided by genomic and transcriptomic profiling

Targeted therapy of advanced parathyroid carcinoma guided by genomic and transcriptomic profiling

Parathyroid carcinoma (PC) is an ultra‐rare malignancy with a high risk of recurrence after surgery. Tumour‐directed systemic treatments for PC are not established. We used whole‐genome and RNA sequencing in four patients with advanced PC to identify molecular alterations that could guide clinical m...

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Bibliographic Details
Main Authors: Maria‐Veronica Teleanu, Carmina T. Fuss, Nagarajan Paramasivam, Sebastian Pirmann, Andreas Mock, Christoph Terkamp, Stefan Kircher, Laura‐Sophie Landwehr, Christina Lenschow, Nicolas Schlegel, Albrecht Stenzinger, Arne Jahn, Martin Fassnacht, Hanno Glimm, Daniel Hübschmann, Stefan Fröhling, Matthias Kroiss
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Molecular Oncology
Subjects:
immune checkpoint inhibition
mutational signature
RNA sequencing
tumour mutational burden
tyrosine kinase inhibition
whole‐genome sequencing
Online Access:https://doi.org/10.1002/1878-0261.13398

Internet

https://doi.org/10.1002/1878-0261.13398

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