Evaluation of the Central Effects of Systemic Lentiviral-Mediated Leptin Delivery in Streptozotocin-Induced Diabetic Rats

Evaluation of the Central Effects of Systemic Lentiviral-Mediated Leptin Delivery in Streptozotocin-Induced Diabetic Rats

Type 1 diabetes (T1D) is characterized by hyperphagia, hyperglycemia and activation of the hypothalamic–pituitary–adrenal (HPA) axis. We have reported previously that daily leptin injections help to alleviate these symptoms. Therefore, we hypothesized that leptin gene therapy could help to normalize...

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Bibliographic Details
Main Authors: Kimberly A. Clark, Andrew C. Shin, Madhu P. Sirivelu, Ramya C. MohanKumar, Sreenivasa R. Maddineni, Ramesh Ramachandran, Puliyur S. MohanKumar, Sheba M. J. MohanKumar
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
diabetes
leptin
stress
hypothalamus
norepinephrine
corticosterone
Online Access:https://www.mdpi.com/1422-0067/22/24/13197

Internet

https://www.mdpi.com/1422-0067/22/24/13197

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