Evaluation of the Central Effects of Systemic Lentiviral-Mediated Leptin Delivery in Streptozotocin-Induced Diabetic Rats
Type 1 diabetes (T1D) is characterized by hyperphagia, hyperglycemia and activation of the hypothalamic–pituitary–adrenal (HPA) axis. We have reported previously that daily leptin injections help to alleviate these symptoms. Therefore, we hypothesized that leptin gene therapy could help to normalize...
Main Authors: | Kimberly A. Clark, Andrew C. Shin, Madhu P. Sirivelu, Ramya C. MohanKumar, Sreenivasa R. Maddineni, Ramesh Ramachandran, Puliyur S. MohanKumar, Sheba M. J. MohanKumar |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-12-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/22/24/13197 |
Similar Items
-
Angiopoietin-Like Growth Factor Involved in Leptin Signaling in the Hypothalamus
by: Yunseon Jang, et al.
Published: (2021-03-01) -
Prenatal exposure to bisphenol A and/or diethylhexyl phthalate alters stress responses in rat offspring in a sex- and dose-dependent manner
by: Amrita Kaimal, et al.
Published: (2023-12-01) -
Multi-Organ Increase in Norepinephrine Levels after Central Leptin Administration and Diet-Induced Obesity
by: Daniela Fernandois, et al.
Published: (2023-11-01) -
High Maternal Omega-3 Supplementation Dysregulates Body Weight and Leptin in Newborn Male and Female Rats: Implications for Hypothalamic Developmental Programming
by: Soniya Xavier, et al.
Published: (2020-12-01) -
Leptin revisited: The role of leptin in starvation
by: Rachel J. Perry
Published: (2018-09-01)