The protective effect of intrasplenic transplantation of Ad-IL-18BP/IL-4 gene-modified fetal hepatocytes on ConA-induced hepatitis in mice.

The protective effect of intrasplenic transplantation of Ad-IL-18BP/IL-4 gene-modified fetal hepatocytes on ConA-induced hepatitis in mice.

Concanavalin A (ConA)-induced hepatitis is an experimental murine model mirroring the pathology of human autoimmune hepatitis.To investigate the effects of intrasplenically transplanted fetal hepatocytes (BNL.CL2) transfected with recombinant adenovirus vector expressing the IL-18 binding protein (I...

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Bibliographic Details
Main Authors: Xueting Shao, Yun Qian, Chenhuai Xu, Bo Hong, Wanhong Xu, Ling Shen, Changzhong Jin, Zhigang Wu, Xiangmin Tong, Hangping Yao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3596329?pdf=render

Internet

http://europepmc.org/articles/PMC3596329?pdf=render

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