Domain loss enabled evolution of novel functions in the snake three-finger toxin gene superfamily

Abstract Three-finger toxins (3FTXs) are a functionally diverse family of toxins, apparently unique to venoms of caenophidian snakes. Although the ancestral function of 3FTXs is antagonism of nicotinic acetylcholine receptors, redundancy conferred by the accumulation of duplicate genes has facilitat...

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Bibliographic Details
Main Authors: Ivan Koludarov, Tobias Senoner, Timothy N. W. Jackson, Daniel Dashevsky, Michael Heinzinger, Steven D. Aird, Burkhard Rost
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40550-0