Domain loss enabled evolution of novel functions in the snake three-finger toxin gene superfamily
Abstract Three-finger toxins (3FTXs) are a functionally diverse family of toxins, apparently unique to venoms of caenophidian snakes. Although the ancestral function of 3FTXs is antagonism of nicotinic acetylcholine receptors, redundancy conferred by the accumulation of duplicate genes has facilitat...
Main Authors: | Ivan Koludarov, Tobias Senoner, Timothy N. W. Jackson, Daniel Dashevsky, Michael Heinzinger, Steven D. Aird, Burkhard Rost |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-08-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-40550-0 |
Similar Items
-
Snake venom NAD glycohydrolases: primary structures, genomic location, and gene structure
by: Ivan Koludarov, et al.
Published: (2019-02-01) -
The Snake with the Scorpion’s Sting: Novel Three-Finger Toxin Sodium Channel Activators from the Venom of the Long-Glanded Blue Coral Snake (Calliophis bivirgatus)
by: Daryl C. Yang, et al.
Published: (2016-10-01) -
Electric Blue: Molecular Evolution of Three-Finger Toxins in the Long-Glanded Coral Snake Species <i>Calliophis bivirgatus</i>
by: Daniel Dashevsky, et al.
Published: (2021-02-01) -
Three-Fingered RAVERs: Rapid Accumulation of Variations in Exposed Residues of Snake Venom Toxins
by: Kartik Sunagar, et al.
Published: (2013-11-01) -
Polyamines as Snake Toxins and Their Probable Pharmacological Functions in Envenomation
by: Steven D. Aird, et al.
Published: (2016-09-01)