An Ethnobotanical, Phytochemical Analysis, Antimicrobial and Biological Studies of <i>Pulicaria crispa</i> as a Graze Promising Shrub

Due to the global issue of antimicrobial resistance, one of the most significant challenges in microbiological research is to develop a replacement antibiotic with minimal adverse effects. The wild shrub <i>Pulicaria crispa</i> (gethgath) has been traditionally used for camel and ruminan...

Full description

Bibliographic Details
Main Authors: Mashail N. AlZain, Fawziah M. Albarakaty, Rehab M. A. El-Desoukey
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Life
Subjects:
Online Access:https://www.mdpi.com/2075-1729/13/11/2197
_version_ 1797458643204964352
author Mashail N. AlZain
Fawziah M. Albarakaty
Rehab M. A. El-Desoukey
author_facet Mashail N. AlZain
Fawziah M. Albarakaty
Rehab M. A. El-Desoukey
author_sort Mashail N. AlZain
collection DOAJ
description Due to the global issue of antimicrobial resistance, one of the most significant challenges in microbiological research is to develop a replacement antibiotic with minimal adverse effects. The wild shrub <i>Pulicaria crispa</i> (gethgath) has been traditionally used for camel and ruminant grazing. While prior research has demonstrated its antimicrobial properties against human diseases, no investigations have been conducted on its efficacy against animal pathogens. The objective of this study is to explore the ethnobotanical, phytochemical, antioxidant, anticancer, and antimicrobial activity of <i>Pulicaria crispa</i> aqueous and solvent extracts against a range of standard and animal pathogens. All of the extracts demonstrated antimicrobial, antioxidant, and anticancer properties, containing bioactive compounds. Notably, the ethyl acetate extract of <i>P. crispa</i> exhibited the strongest antimicrobial activity against tested Gram-positive and Gram-negative bacteria and fungi. The chloroform fraction displayed the highest antioxidant activity. Additionally, the ethyl acetate fraction showed promising anticancer activity against breast (MCF-7) and lung (A549) cancer cells. These findings confirm that <i>Pulicaria crispa</i> is a valuable shrub with potential applications as a natural alternative for antimicrobial, antioxidant, and anticancer treatments in both human and veterinary medicine.
first_indexed 2024-03-09T16:40:06Z
format Article
id doaj.art-6575ef75376942b88291c8e15cb75cb8
institution Directory Open Access Journal
issn 2075-1729
language English
last_indexed 2024-03-09T16:40:06Z
publishDate 2023-11-01
publisher MDPI AG
record_format Article
series Life
spelling doaj.art-6575ef75376942b88291c8e15cb75cb82023-11-24T14:52:33ZengMDPI AGLife2075-17292023-11-011311219710.3390/life13112197An Ethnobotanical, Phytochemical Analysis, Antimicrobial and Biological Studies of <i>Pulicaria crispa</i> as a Graze Promising ShrubMashail N. AlZain0Fawziah M. Albarakaty1Rehab M. A. El-Desoukey2Department of Biology, College of Sciences, Princess Nourah Bint Abdulrahman University, Riyadh 11451, Saudi ArabiaDepartment of Biology, Faculty of Applied Science, Umm Al-Qura University, Makkah Al Mukarramah P.O. Box 715, Saudi ArabiaMicrobiology and Immunology Department, National Research Centre, Giza 12622, EgyptDue to the global issue of antimicrobial resistance, one of the most significant challenges in microbiological research is to develop a replacement antibiotic with minimal adverse effects. The wild shrub <i>Pulicaria crispa</i> (gethgath) has been traditionally used for camel and ruminant grazing. While prior research has demonstrated its antimicrobial properties against human diseases, no investigations have been conducted on its efficacy against animal pathogens. The objective of this study is to explore the ethnobotanical, phytochemical, antioxidant, anticancer, and antimicrobial activity of <i>Pulicaria crispa</i> aqueous and solvent extracts against a range of standard and animal pathogens. All of the extracts demonstrated antimicrobial, antioxidant, and anticancer properties, containing bioactive compounds. Notably, the ethyl acetate extract of <i>P. crispa</i> exhibited the strongest antimicrobial activity against tested Gram-positive and Gram-negative bacteria and fungi. The chloroform fraction displayed the highest antioxidant activity. Additionally, the ethyl acetate fraction showed promising anticancer activity against breast (MCF-7) and lung (A549) cancer cells. These findings confirm that <i>Pulicaria crispa</i> is a valuable shrub with potential applications as a natural alternative for antimicrobial, antioxidant, and anticancer treatments in both human and veterinary medicine.https://www.mdpi.com/2075-1729/13/11/2197antimicrobial<i>Pulicaria crispa</i>gethgathgrazing herbsantioxidantanimal pathogen
spellingShingle Mashail N. AlZain
Fawziah M. Albarakaty
Rehab M. A. El-Desoukey
An Ethnobotanical, Phytochemical Analysis, Antimicrobial and Biological Studies of <i>Pulicaria crispa</i> as a Graze Promising Shrub
Life
antimicrobial
<i>Pulicaria crispa</i>
gethgath
grazing herbs
antioxidant
animal pathogen
title An Ethnobotanical, Phytochemical Analysis, Antimicrobial and Biological Studies of <i>Pulicaria crispa</i> as a Graze Promising Shrub
title_full An Ethnobotanical, Phytochemical Analysis, Antimicrobial and Biological Studies of <i>Pulicaria crispa</i> as a Graze Promising Shrub
title_fullStr An Ethnobotanical, Phytochemical Analysis, Antimicrobial and Biological Studies of <i>Pulicaria crispa</i> as a Graze Promising Shrub
title_full_unstemmed An Ethnobotanical, Phytochemical Analysis, Antimicrobial and Biological Studies of <i>Pulicaria crispa</i> as a Graze Promising Shrub
title_short An Ethnobotanical, Phytochemical Analysis, Antimicrobial and Biological Studies of <i>Pulicaria crispa</i> as a Graze Promising Shrub
title_sort ethnobotanical phytochemical analysis antimicrobial and biological studies of i pulicaria crispa i as a graze promising shrub
topic antimicrobial
<i>Pulicaria crispa</i>
gethgath
grazing herbs
antioxidant
animal pathogen
url https://www.mdpi.com/2075-1729/13/11/2197
work_keys_str_mv AT mashailnalzain anethnobotanicalphytochemicalanalysisantimicrobialandbiologicalstudiesofipulicariacrispaiasagrazepromisingshrub
AT fawziahmalbarakaty anethnobotanicalphytochemicalanalysisantimicrobialandbiologicalstudiesofipulicariacrispaiasagrazepromisingshrub
AT rehabmaeldesoukey anethnobotanicalphytochemicalanalysisantimicrobialandbiologicalstudiesofipulicariacrispaiasagrazepromisingshrub
AT mashailnalzain ethnobotanicalphytochemicalanalysisantimicrobialandbiologicalstudiesofipulicariacrispaiasagrazepromisingshrub
AT fawziahmalbarakaty ethnobotanicalphytochemicalanalysisantimicrobialandbiologicalstudiesofipulicariacrispaiasagrazepromisingshrub
AT rehabmaeldesoukey ethnobotanicalphytochemicalanalysisantimicrobialandbiologicalstudiesofipulicariacrispaiasagrazepromisingshrub