An Ethnobotanical, Phytochemical Analysis, Antimicrobial and Biological Studies of <i>Pulicaria crispa</i> as a Graze Promising Shrub
Due to the global issue of antimicrobial resistance, one of the most significant challenges in microbiological research is to develop a replacement antibiotic with minimal adverse effects. The wild shrub <i>Pulicaria crispa</i> (gethgath) has been traditionally used for camel and ruminan...
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MDPI AG
2023-11-01
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Online Access: | https://www.mdpi.com/2075-1729/13/11/2197 |
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author | Mashail N. AlZain Fawziah M. Albarakaty Rehab M. A. El-Desoukey |
author_facet | Mashail N. AlZain Fawziah M. Albarakaty Rehab M. A. El-Desoukey |
author_sort | Mashail N. AlZain |
collection | DOAJ |
description | Due to the global issue of antimicrobial resistance, one of the most significant challenges in microbiological research is to develop a replacement antibiotic with minimal adverse effects. The wild shrub <i>Pulicaria crispa</i> (gethgath) has been traditionally used for camel and ruminant grazing. While prior research has demonstrated its antimicrobial properties against human diseases, no investigations have been conducted on its efficacy against animal pathogens. The objective of this study is to explore the ethnobotanical, phytochemical, antioxidant, anticancer, and antimicrobial activity of <i>Pulicaria crispa</i> aqueous and solvent extracts against a range of standard and animal pathogens. All of the extracts demonstrated antimicrobial, antioxidant, and anticancer properties, containing bioactive compounds. Notably, the ethyl acetate extract of <i>P. crispa</i> exhibited the strongest antimicrobial activity against tested Gram-positive and Gram-negative bacteria and fungi. The chloroform fraction displayed the highest antioxidant activity. Additionally, the ethyl acetate fraction showed promising anticancer activity against breast (MCF-7) and lung (A549) cancer cells. These findings confirm that <i>Pulicaria crispa</i> is a valuable shrub with potential applications as a natural alternative for antimicrobial, antioxidant, and anticancer treatments in both human and veterinary medicine. |
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format | Article |
id | doaj.art-6575ef75376942b88291c8e15cb75cb8 |
institution | Directory Open Access Journal |
issn | 2075-1729 |
language | English |
last_indexed | 2024-03-09T16:40:06Z |
publishDate | 2023-11-01 |
publisher | MDPI AG |
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series | Life |
spelling | doaj.art-6575ef75376942b88291c8e15cb75cb82023-11-24T14:52:33ZengMDPI AGLife2075-17292023-11-011311219710.3390/life13112197An Ethnobotanical, Phytochemical Analysis, Antimicrobial and Biological Studies of <i>Pulicaria crispa</i> as a Graze Promising ShrubMashail N. AlZain0Fawziah M. Albarakaty1Rehab M. A. El-Desoukey2Department of Biology, College of Sciences, Princess Nourah Bint Abdulrahman University, Riyadh 11451, Saudi ArabiaDepartment of Biology, Faculty of Applied Science, Umm Al-Qura University, Makkah Al Mukarramah P.O. Box 715, Saudi ArabiaMicrobiology and Immunology Department, National Research Centre, Giza 12622, EgyptDue to the global issue of antimicrobial resistance, one of the most significant challenges in microbiological research is to develop a replacement antibiotic with minimal adverse effects. The wild shrub <i>Pulicaria crispa</i> (gethgath) has been traditionally used for camel and ruminant grazing. While prior research has demonstrated its antimicrobial properties against human diseases, no investigations have been conducted on its efficacy against animal pathogens. The objective of this study is to explore the ethnobotanical, phytochemical, antioxidant, anticancer, and antimicrobial activity of <i>Pulicaria crispa</i> aqueous and solvent extracts against a range of standard and animal pathogens. All of the extracts demonstrated antimicrobial, antioxidant, and anticancer properties, containing bioactive compounds. Notably, the ethyl acetate extract of <i>P. crispa</i> exhibited the strongest antimicrobial activity against tested Gram-positive and Gram-negative bacteria and fungi. The chloroform fraction displayed the highest antioxidant activity. Additionally, the ethyl acetate fraction showed promising anticancer activity against breast (MCF-7) and lung (A549) cancer cells. These findings confirm that <i>Pulicaria crispa</i> is a valuable shrub with potential applications as a natural alternative for antimicrobial, antioxidant, and anticancer treatments in both human and veterinary medicine.https://www.mdpi.com/2075-1729/13/11/2197antimicrobial<i>Pulicaria crispa</i>gethgathgrazing herbsantioxidantanimal pathogen |
spellingShingle | Mashail N. AlZain Fawziah M. Albarakaty Rehab M. A. El-Desoukey An Ethnobotanical, Phytochemical Analysis, Antimicrobial and Biological Studies of <i>Pulicaria crispa</i> as a Graze Promising Shrub Life antimicrobial <i>Pulicaria crispa</i> gethgath grazing herbs antioxidant animal pathogen |
title | An Ethnobotanical, Phytochemical Analysis, Antimicrobial and Biological Studies of <i>Pulicaria crispa</i> as a Graze Promising Shrub |
title_full | An Ethnobotanical, Phytochemical Analysis, Antimicrobial and Biological Studies of <i>Pulicaria crispa</i> as a Graze Promising Shrub |
title_fullStr | An Ethnobotanical, Phytochemical Analysis, Antimicrobial and Biological Studies of <i>Pulicaria crispa</i> as a Graze Promising Shrub |
title_full_unstemmed | An Ethnobotanical, Phytochemical Analysis, Antimicrobial and Biological Studies of <i>Pulicaria crispa</i> as a Graze Promising Shrub |
title_short | An Ethnobotanical, Phytochemical Analysis, Antimicrobial and Biological Studies of <i>Pulicaria crispa</i> as a Graze Promising Shrub |
title_sort | ethnobotanical phytochemical analysis antimicrobial and biological studies of i pulicaria crispa i as a graze promising shrub |
topic | antimicrobial <i>Pulicaria crispa</i> gethgath grazing herbs antioxidant animal pathogen |
url | https://www.mdpi.com/2075-1729/13/11/2197 |
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