Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1

Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1

Carnosine (β-alanyl-L-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. Carnosine is involved in cellular defense mechanisms against oxidative stress, including the inhibition of amyloid-beta (Aβ) aggregation a...

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Bibliographic Details
Main Authors: Giuseppe Caruso, Claudia G. Fresta, Nicolò Musso, Mariaconcetta Giambirtone, Margherita Grasso, Simona F. Spampinato, Sara Merlo, Filippo Drago, Giuseppe Lazzarino, Maria A. Sortino, Susan M. Lunte, Filippo Caraci
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cells
Subjects:
carnosine
microglia
Alzheimer’s disease
neurodegeneration
neuroinflammation
reactive oxygen and nitrogen species
oxidative stress
TGF-β1
Online Access:http://www.mdpi.com/2073-4409/8/1/64

Internet

http://www.mdpi.com/2073-4409/8/1/64

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