Computer Simulation of TSP1 Inhibition of VEGF–Akt–eNOS: An Angiogenesis Triple Threat

Computer Simulation of TSP1 Inhibition of VEGF–Akt–eNOS: An Angiogenesis Triple Threat

The matricellular protein thrombospondin-1 (TSP1) is a potent inhibitor of angiogenesis. Specifically, TSP1 has been experimentally shown to inhibit signaling downstream of vascular endothelial growth factor (VEGF). The molecular mechanism of this inhibition is not entirely clear. We developed a det...

Ful tanımlama

Detaylı Bibliyografya
Asıl Yazarlar: Hojjat Bazzazi, Yu Zhang, Mohammad Jafarnejad, Jeffrey S. Isenberg, Brian H. Annex, Aleksander S. Popel
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2018-05-01
Seri Bilgileri:Frontiers in Physiology
Konular:
TSP1
CD47
VEGFR2
systems biology
systems pharmacology
computational modeling
Online Erişim:https://www.frontiersin.org/article/10.3389/fphys.2018.00644/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.00644/full

Benzer Materyaller