Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics.

Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics.

The HIV-1 envelope glycoprotein (Env) trimer is located on the surface of the virus and is the target of broadly neutralizing antibodies (bNAbs). Recombinant native-like soluble Env trimer mimetics, such as SOSIP trimers, have taken a central role in HIV-1 vaccine research aimed at inducing bNAbs. W...

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Bibliographic Details
Main Authors: Alba Torrents de la Peña, Kimmo Rantalainen, Christopher A Cottrell, Joel D Allen, Marit J van Gils, Jonathan L Torres, Max Crispin, Rogier W Sanders, Andrew B Ward
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007920

Internet

https://doi.org/10.1371/journal.ppat.1007920

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